动脉粥样硬化与肺炎衣原体及血清C-反应蛋白和肿瘤坏死因子及IL-6关系的研究

Relation of Chlamydia Pneunomiae,Tumor Necrosis Factor,Interleukin-6 and C-Reactive Protein with Atherosclerosis

目的探讨动脉粥样硬化与肺炎衣原体及C-反应蛋白?肿瘤坏死因子(TNF-α)?IL-6等炎症因子和炎症递质的合成释放的关系。方法测定动脉粥样硬化组60例患者的血清肺炎衣原体抗体IgG?IgM,CRP,TNF-α,IL-6水平。并和正常健康者40例(健康对照组)作对照。结果动脉粥样硬化组肺炎衣原体抗体IgG阳性检出率明显高于健康对照组(P<0.01),而IgM间差异无统计学意义(P>0.05)。动脉粥样硬化组与健康对照组CRP、TNF-α、IL-6水平间差异均有统计学意义(P<0.05)。结论肺炎衣原体以及肺炎衣原体介导的CRP、TNF-α、IL-6等炎症因子和炎症递质的合成释放与动脉粥样硬化存在一定的关系。

Objective To explore the relation of Chlamydia Pneunomiae （ CPN）, Tumor Necrosis Factor （TNF）, Interleukin -6 （IL-6） and C -Reactive Proten （CRP） with Atherosclerosis （AS）. Methods The serum Chlamydia Pneunomiae IgG , lgM, Tumor Necrosis Factor, Interleukin - 6 and C - Reactive levers were measured by ELISA in 60 patients with Atherosclerosis and 40 normal cases control group. Results Serum CPN IgG lever was significantly higher in AS group than in normal control group （ P 〈0. 01 ）, but serum CPN IgM lever has none （ P 〉0. 05）. Serum TNF, IL -6 and CRP levers were significantly higher in AS group than in normal control group （ P 〈 0. 05）. Condusion Relation was existent in Atherosclerosis and CPN, release of Inflammatory Mediator inclouding TNF, IL -6 and CRP.