摘要
目的观察舒血宁注射液联合辛伐他汀治疗不稳定性心绞痛的疗效与安全性。方法96例患者随机分为两组,每组48例,两组均常规治疗,对照组加用舒血宁注射液20ml用5%葡萄糖注射液或0.9%氯化钠溶液500ml稀释后静脉滴注,1次/d,共7d,治疗组在对照组的基础上,同时口服辛伐他汀片20mg每晚口服1次,共7d,出院后继续治疗1~3个月。观察两组心绞痛、心电图改善疗效及血脂变化。结果治疗组心绞痛改善总有效率为93.21%,对照组72.68%,;心电图改善总有效率分别为76.0%及53.6%。治疗组治疗后心绞痛发作频率减少、发作间隔延长,心电图及动态心电图心肌缺血亦明显改善情况,与对照组及治疗前比较差异均有统计学意义(P<0.01)。治疗组治疗后高密度脂蛋白胆固醇增高,总胆固醇、低密度脂蛋白胆固醇、三酰甘油均下降,与治疗前比较及与对照组比较均有显著性差异(P<0.01),而对照组治疗前、后变化不明显(P>0.05)。两组均无不良反应发生。结论舒血宁联合辛伐他汀较单用舒血宁对不稳定性心绞痛治疗更能改善不稳定性心绞痛发作及降血脂,安全可靠。
Objective Evaluation Shuxuening injection simvastatin treatment of unstable angina efficacy and safety. Methods 96 cases were randomly divided into two groups of 48 cases, conventional treatment in both groups, the control group plus Shuxuening injection with 20 ml of 5% glucose injection fluid or diluted 500 ml saline infusion, 1/d, 7 d, the treatment group in the control group on the basis of oral simvastatin at the same time every night, 20 mg oral tablets, a total of 7 d, discharged after treatment 1 to 3 months. Angina were observed, ECG and blood lipid changes to improve efficacy. Results Angina results of the treatment group to improve the overall efficiency of 93.21% , the control group 72.68% ; ECG to improve the overall response rate was 76.0% and 53.6%. There were no adverse reactions. Conclusion Shuxuening Joint than simvastatin alone Shuxuening treatment of unstable angina can improve unstable angina attack and hypolipidemic, safe and reliable.
出处
《实用心脑肺血管病杂志》
2009年第3期182-183,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
舒血宁注射液
辛伐他汀
心绞痛
心肌梗死
Shuxuening injection
Simvastatin
Angina pectoris
Myocardial infarction