无抽搐电休克与氟哌啶醇针剂控制分裂症兴奋、躁动疗效对照研究

A Comparative Study of the Effect of MECT and Haloperidol in Jection on the Agitated Behavior of Psychotic Patients

目的比较无抽搐电休克(MECT)与氟哌啶醇针剂治疗伴有兴奋攻击性行为分裂症的疗效和安全性。方法对48例伴有兴奋攻击行为的精神分裂症患者随机分成2组,A组为在原服用抗精神病药物治疗的基础上联合无抽搐电休克治疗。B组为在原服用抗精神病药物治疗的基础上联合氟哌啶醇针剂。分别在1、2、3、4周末进行PANSS评定,并在第4周末评定疗效。并用副作用量表(TESS)和韦氏记忆量表(WMS)评定不良反应。结果PANSS量表的兴奋攻击因子评分A组在治疗的第2周末。B组在第4周末均有明显下降。治疗结束时MECT组总体疗效明显高于氟哌啶醇针剂组。A、B2组间比较无明显差异,2组不良反应无明显差异。结论MECT和氟哌啶醇针剂治疗急性期兴奋患者的激越症状均有很好疗效.MECT的疗效、依丛性、疗效指数更有优势。

Objective To compare the effect of modern MECT and haloperidol injection on the agitation of acute psychotic patients and their serum prolactin levels.Methods Forty eight acute and agitated psychotic patients were randomly divided into two groups with MECT tar haloperidol injection respectively.All the patients were evaluated with the positive and negative syndrome scale （PANSS）,Ihe treatment emergent symptoms scale（TESS）and the weii＇s memory scale（WMS）before treatment and at the lth. 2th. 3th. 4th week after treatment. Results Compare with the patients before treatment the score of the agitation subscale of PANSS in both groups were significantly lower after treatment. In addition,at the 2th week,these scores were significantly lower in MECTgroup than in haloperidol injection group,at the 4th week,these score were significantly lower in haloperidol in injection group. Conclusion It is suggested that MECThave good efficacy and compliance in the acute Psychotic patients with agitated behavior,and only produce little side effects.