低级别脑神经元-胶质混合性肿瘤MRI及临床特点

The MRI and clinical characteristics of low grade cerebral mixed neuronal-glial tumors

目的分析低级别脑神经元一胶质混合性肿瘤MRI及临床特点。方法回顾病理证实的18例该类患者临床及影像资料。结果患者术前均有癫痫史，14例为药物难治性癫痫。MRI上病变边界清晰，均位于或累及皮层；多呈实性，少数为囊实性或囊性，实性成分更靠近皮层；病变呈长T1长T2信号，部分实性成分为等信号；信号均匀少有强化，囊实性者可小壁结节样强化，壁可部分强化；肿瘤无明显占位效应，瘤周水肿少见或轻微。术后平均随访25．6个月无复发。结论低级别脑神经元一胶质混合性肿瘤位于或累及皮层，多以癫痫起病，手术全切可较好控制症状。

Objective To Analyze the MRI and clinical features of low grade cerebral mixed neuronal-glial tumors. Method We retrospectively studied the clinical features and imaging data of 18 cases of low grade cerebral mixed neuronal-glial tumors which were pathologically confirmed. Results All the patients had a history of epilepsy, of which 14 cases onset with drug intractable epilepsy. The lesions showed clear sharp border on MRI and located or involved in the cortex. They were solid for the vast majority of them, involving a small portion of solid-cystic combination or cystic mass merely. The solid component situated closer to the cortex. Most of them manifested as slightly hypointense on T1WI and hyperintense relative gray matter on T2WI,involving a small part of isointense solid lesions on MRI scan. The signals were even and enhancement were rare. The solid-cystic lesions could be small nodular enhancement. They showed no mass effect,with rare or minor edema. No recurrence occurred during a mean follow-up period of 25.6 months. Conclusions Most of the low grade cerebral mixed neuronal-glial tumors occurred or involved in the cortex, onset with drug intractable epilepsy. Total surgical removal lesions can control the clinical symptoms perfectly.