瘦素、脂联素与子痫前期—子痫关系的研究

Study of the relationship among leptin and adiponectin and preeclampsia

目的:探讨子痫前期(PE)患者血清瘦素、脂联素水平的变化及其意义。方法:选择38例子痫前期孕妇作为研究组,其中子痫前期轻度患者16例(B组),子痫前期重度患者22例(C组);选择同期分娩的正常孕妇40例作为对照组(A组)。采用放免法检测血清瘦素水平,采用ELISA法检测血清脂联素水平。同时检测患者尿蛋白、肾功能(BUN、Cr)水平。结果:(1)PE重度组患者血清瘦素水平(29.45±7.93)ng/ml,最高;PE轻度组患者血清瘦素水平(16.64±5.29)ng/ml,居中;对照组血清瘦素水平(10.51±3.16)ng/ml,最低,三者两两相比,差异有统计学意义(P<0.05)。PE重度组患者血清脂联素水平(1.06±0.35)mg/L,最低;PE轻度组患者血清脂联素水平(2.33±1.46)mg/L,居中;对照组脂联素水平(4.21±0.96)mg/L,最高,三者两两相比,差异有统计学意义(P<0.05)。(2)子痫前期患者血清瘦素和脂联素呈高度负相关(r=-0.825,P<0.01)。结论:瘦素、脂联素在PE的发病过程中可能起一定的作用,高瘦素血症和低脂联素血症可能与PE的发生、发展有关。

Objective： To explore the role of eptin and adiponectin in the pathogenesis of preeclampcia. Methods： Choosing 38 PE patients as research group,including 16 patients with mild preeclapeia （ MPE, group B） and 22 patients with severe preeclapcia （SPE, group C）, choosing 40 normal pregnant women（NPW） who deliver in the corresponding period as contrast group （group A）. The serum levels of leptin were measured using radioimmunoassay. The serum levels of adiponectin were measured using the enzyme-linked immunosorbent, urine protin and kidney function were measured meanwhile. Results： （1）The serum levels of leptin and adiponectin in three groups were all significantly different in statistics（P〈 0. 05）. The serum levels of leptin in women with SPE was maximal, those with MPE was medium, those NPW was minimum; while the serum levels of adiponeetin in women with SPE was minimum, those with MPE was medium, those with NPW was maximal. （2）There was a highly negative correlation between the serum levels of leptin and adiponectin in PE patients （r= 0. 825, P〈 0.01）. Conclusions： Leptin and adiponectin may be involved in the pathogenesis of PE,moreover,high serum levels of leptin and low adiponectin are associated with the occurrence and elovement of this disease.