小剂量氟康唑预防新生儿重症监护室真菌感染的临床观察

Preventive Effect of Small Dosage of Fluconazol on Fungal Infection in Neonatal Intensive Care Unit

目的:观察应用小剂量氟康唑预防新生儿重症监护室真菌感染的效果。方法:2006年度收治的284例为对照组,2007年度收治的416例为预防组。预防组给予3mg/(kg.次)的氟康唑静脉滴注,每3d一次。结果:2006年真菌的感染率为7.04%,2007年真菌感染率为2.16%,两组比较差异有统计学意义(χ2=10.12,P<0.01)。结论:小剂量的氟康唑预防新生儿重症监护室真菌感染有效,相对安全。

Objective：To evaluate the effect of low dosage of fluconazole in preventing invasive fungal infection in the neonatal intensive care unit （NICU）. Methods： There were 416 infants in the fluconazole group in the year of 2007, while 284 infants in the control group in 2006. The fluconazole group was administered at a dose of 3 mg/kg every third day during a week. Results： The incidence of fungal infection decreased from 7.04% in 2006 to 2.16% in 2007 （Х^2 = 10. 12, P 〈0.01 ）. Conclusions： The small dosage of fluconazole is effective and relatively safe to prevent invasive fungal infection in the NICU.