连续胰岛素皮下输注强化治疗糖尿病合并肺结核的临床研究

Clinical Study on Intensive Treatment of Diabetes Combined with Pulmonary Tuberculosis with Continuous Subcutaneous Insulin Infusion

目的:探讨胰岛素泵连续皮下注射治疗(CSII)对糖尿病合并肺结核患者的临床效果。方法:51例糖尿病合并肺结核患者随机被分CSII组和MSII组,CSII组采用连续胰岛素皮下输注治疗方案,MSII组采用多次皮下注射治疗治疗方案,同时两组患者均给予抗痨治疗。观察痰菌阴转和病灶吸收情况,患者血糖达标时间、胰岛素用量、低血糖发生率、停用胰岛素后血糖良好控制维持时间。结果:1月后及3月后CSII组痰菌阴转率明显升高,病灶吸收情况好转,与MSII组比较有显著性差异(P<0.05)。 CSII组与MSII组相比血糖达标时间短、胰岛素用量少、停用胰岛素后血糖良好控制维持时间长、低血糖发生率低(P<0.05)。结论:CSII治疗糖尿病合并肺结核病能尽快达到良好控制病情,以促进痰菌转阴。

Objective： To investigate and analyze the clinical effect of diabetes combined with pulmonary tuberculosis with continuous subcutaneous insulin infusion （CSⅡ）.Methods： 51 cases of diabetes combined with pulmonary tuberculosis were randomly divided CSⅡ group and the MSⅡ group,CSⅡ group was treated with CSⅡ,MSⅡ group was treated with subcutaneous injection therapy treatment.at the same time,two groups were given anti-TB treatment.Observation of sputum conversion and absorption of lesions,blood glucose in patients with standard time,the amount of insulin,the incidence of low blood sugar,insulin suspended after blood sugar control to maintain a good time.Results： At the 1-month and 3 months after,the sputum conversion rate and absorption of lesions significantly increased in the CSⅡ group,and compared with the MSⅡ group the difference was significant （P〈0.05）.CSⅡ group and MSⅡ group compared to standard blood sugar a short time,use less insulin,insulin-out after a good blood sugar control to maintain the long hours,low incidence of hypoglycemia （P〈0.05）.Conclusion： CSⅡ treatment of diabetes combined with pulmonary tuberculosis can better control the disease and promote negative sputum.