阿德福韦酯治疗乙肝疗效分析

Observation on the Therapeutic Effect of ADV on HBV

目的:为探讨阿甘定(阿德福韦酯/ Adefovir dipivoxil/ADV)在临床上用于抗病毒、保肝、抗肝纤维化的作用。方法:将慢性肝炎、肝炎肝硬化患者分为两个组,阿甘定治疗组和苦参素胶囊治疗组进行比较。结果:阿甘定治疗组HBV-DNA下降较快,转阴比例较高,ALT正常和肝纤维化指标改善的效果都比较好。阿甘定对发YMDD变异的病例同样有效。结论:口服阿甘定方便,抗病毒作用可靠,并能改善肝功能,抗肝纤维化,无相关抗药性,耐受性和安全性良好,可作为临床抗病毒的首选药物。

Objective： The main purpose of this paper is to further investigate the antiviral,liver-protectionanti-hepatic-fibrosis efficacy of ADV （Adefovir dipivoxil） in clinical treatments.Methods： In our study,patients with chronic hepatitis and cirrhosis were divided into two comparable groups,ADV treatment group and oxymtrine-treatment group,to observe and idcntify the efficacy of ADV.Results： Clinical treatment results indicate that ADV-treatment group achieved amorer apid fall in HBV-DNA a higer rate of HBeAg seroconversion and better efficiency inALT normalization and fibrosis regression,ADV is also effective for YMDD mutant cases.It is concluded that oral ADVis convenient and had good antiviral impacts.Conclusion： It can improve the liver function,regress hepatic fibrosisand no significant drug interactions have been observed.It may become the first choice for clinical antivival treatment.