小剂量左旋甲状腺素辅助治疗慢性心力衰竭临床观察

Clinical Effect of Tetraiodothyronine in Low Dose on Chronic Heart Failure Patients

目的:探讨慢性心力衰竭患者体内甲状腺素异常情况及小剂量左旋甲状腺素的对慢性心力衰竭的治疗作用。方法:将60名慢性心力衰竭患者随机分为治疗1组和治疗2组,30名健康体检者作为对照组,两治疗组病人给予相同的强心、利尿、扩张血管等基础疗法,治疗2组每日另给予左旋甲状腺素片15μg/d,疗程2周,观察三组病人治疗前后甲状腺素水平,治疗1组同治疗2组临床症状及心功能好转情况。结果:治疗1组与治疗2组患者治疗前血清三碘甲状原氨酸水平低于对照组,2周后治疗2组同对照组无明显差异,治疗2组临床治疗效果优于治疗1组(P<0.05)。结论:慢性心力衰竭病人体内存在甲状腺素异常,给予外源性甲状腺素,能够对慢性心力衰竭起到较好的辅助治疗作用。

Objective： To investigate change of Tetraiodothyronine（TH） in serum on Chronic Heart Failure Patients（CHF） and observe the effect of TH on CHF.Methods： Sixty patients treatment were randomly allocated to first experimental group and second experimental group,thirty healthy persons were as control group,the patients in first experimental group and second experimental group receive same treatment,including aspiration,diuresis and enlarging blood vessel.TH were taken to second experimental group with 15μg/d,the concentration of TH in serum were measured in all patients when the treatment beginn and.end clinical effect were estimated.Results： In comparetion with control group,the concentration of triiodothyronine in serum were lower in first experimental group and second experimental group,and were identifical in second experimental group after two weeks.Clinical effect in second experimental group were better than that in first experimental group.Conclusion： The lever of TH in serum was abnormal on CHF patients,and additional TH have a good auxiliary clinical effect on CHF.