甲烷磺酰胺苯乙胺类化合物的合成及抗心律失常活性的研究(Ⅰ)

Synthesis and Antiarrhythmic Activity of SomeMethylsulfonamidophenylethylamino Derivatives

本文以对硝基苯乙胺及取代苯甲醛为原料，经席夫氏碱还原，Ｎ取代反应、铁粉盐酸还原硝基、甲烷磺酰化五步反应，设计合成了１２个甲烷磺酰胺苯乙胺类衍生物。初步药理研究结果表明，这些化合物显示不同程度的抗心律失常活性。

Started from pnitrophenylethylamine and varied substituted benzaldehydes, twelve Nsubstituted methylsulfonamido phenylethylamino derivatives were designed and synthesized through five step chemical reactions. Their chemical structures were determined by IR, 1HNMR and MS. The pharmacological study showed that the target compounds exhibit antiarrhythmic activity to varying degrees in arrhythmic rats induced by aconitine.