酮洛芬β-CD包合物的结构研究

Structure Investigation of Inclusion Complex of Ketoprofen and βcydodextrin

对自制酮洛芬βＣＤ包合物的结构进行了研究。用红外光谱、Ｘ衍射、核磁共振技术研究了酮洛芬βＣＤ包合物的波谱学性质，比较了酮洛芬与βＣＤ形成包合物前后的波谱变化。结果表明：综合图谱解析结果，证实了酮洛芬有部分芳环进入了βＣＤ分子内腔；同时，从酮洛芬分子结构上异丙酸部分的甲基信号产生明显的低场位移（核磁共振谱）的结果，证明是酮洛芬分子的异丙酸及其相连的苯环部分进入βＣＤ分子内腔，形成了包合物。

Infrared (IR), Xray diffraction and nuclear magnetic resonance (NMR, 500 MHz) techniques were utilised for the confirmation of formation of ketoprofen βcyclodextrin(βCD) inclusion complex. It was confirmed, by comprehensive analysis of spectra of these experiments, that partial benzene ring of ketoprofen molecule was included into βCD cavity; and that the benzene ring, jointed with isopropyl acid group, was iucluded into the cavity by judgement of methyl(in isopropyl acid group) signal lowfield shift in NMR spectrum.