尼莫地平的合成工艺改进

Improved Process of Nimodipine

尼莫地平的合成工艺改进①吴苏敏宋明华峰华维一１（中国药科大学制药有限公司，１药物化学研究室，南京２１０００９）关键词尼莫地平；二氢吡啶合成尼莫地平（１），化学名为（±）１，４二氢２，６二甲基４（３硝基苯基）吡啶３，５二羧酸异丙酯２?..

Nimodipine was synthesized by twosteps method. Through the use of appropriate condensation catalyst and cyclation solvent, the total yield was increassed by 15.5%, the reaction time was shortened and the quality was improved.