摘要
为探讨细胞因子与肝硬化形成的关系,对32例肝硬化患者外周血单个核细胞分泌的IL-1、IL-6和TNFα活性水平进行了检测。结果显示,肝硬化患者外周血单个核细胞所产生的IL-1、IL-6和TNFα活性水平较正常对照组显著增高,提示这些细胞因子可能参与了肝硬化的形成过程。
The biological active levels of IL-1, TNFα and IL-6 produced by peripheral blood mononuclear cells (PBMC) were determinated in 32 cases of liver cirrhosis and 20 normal blood donors. The results showed that the biological active levels of IL-1, TNFα and IL-6 produced by PBMC in liver cirrhosis were all obviously higher than those of the normal blood donors(P<0.01). It revealed that the cytokines,such as IL-1,TNFα and IL-6,may play important roles in the formation of liver cirrhosis. The relationship between the biological active levels of cytokines and production of collagen released by Ito cells and liver cells had been discussed.
出处
《天津医药》
CAS
1998年第7期409-411,共3页
Tianjin Medical Journal
基金
天津市卫生局资助课题
