非胰岛素依赖型糖尿病患者尿α_1-微球蛋白与尿微量白蛋白排泄率的相关性分析

The Relationship Between Urinary α_1-microglobulin and Microalbuminuria Excretion Rate in Patients with NIDDM

对51例非胰岛素依赖型糖尿病(NIDDM)患者尿α_1-微球蛋白(α_1-mG)及每分尿微量白蛋白排泄率(UAER)进行检测并比较。结果显示:(1)尿α_1-mG与每分尿微量白蛋白排泄率(UAER)呈显著性正相关(P<0.01)。(2)尿α_1-mG临床糖尿病肾病(DN)组、无DN组与早期DN组比较均有显著性差异(P<0.01)。提示:尿α_1-mG可作为早期糖尿病肾病诊断的敏感指标。

The per minute urinary microalbuminuria excretion rate (UAER) and urinary α1-microglobulin(α1-mG)concentration were measured in 51 patients with NiDDM. The results showed: (l)urinary α1-mG had significant positive correlation with UAER(P<0.01), (2)urinary α1-mG content in the early diabetic ne-phropathy(DN) group as significantly different from clinical DN and non-DN groups(P<0.01). The urinary α1 -mG content might be used as a sensitive marker for early diagnosis of DN.