盐酸阿比朵尔对病毒性心肌炎小鼠的治疗作用

A specific and effective medicine for viral Myocarditis

目的探讨盐酸阿比朵尔对病毒性心肌炎的治疗作用。方法以柯萨奇B3病毒构建小鼠病毒性心肌炎模型,灌胃给予盐酸阿比朵尔药液(高、中、低)3个剂量治疗7 d。然后观察各组小鼠生存率、血清心肌酶活性、心脏匀浆的病毒滴度以及心脏切片的病理变化并计算病理积分。结果与病毒对照组比较,治疗组的小鼠生存率明显增加,心肌病毒繁殖量明显降低,心肌酶活性明显下降,心肌炎病灶明显减轻。结论盐酸阿比朵尔对病毒性心肌炎具有一定的治疗作用。

Objective Study Arbidol Hydrochloride （AHYD） treatment effect on viral Myocarditis. Methods The model of viral Myocarditis infected by Coxsaekie B3 were treated with 3 concentrations （high, middle, low） of AHYD by the intragas- tric AHYD ministration, after 7 d, observed survival rate, cardiac enzymes, virus titer and pathological section of myoeardium, and count path - index. Results Compared with results of viral control, data of treatment groups AHYD showd that survival rate increased, virus proliferation and cardiac enzymes decreased, focus of infection relieved. Conclusions AHDY has a definite medicinal effect on viral Myoearditis.