神经核蛋白-γ与肿瘤相关性的研究进展

Progress of study on synuclein-gama and tumor

神经核蛋白(γ-syn)是神经核蛋白家族成员,正常主要位于细胞质和神经元的轴突内,其异常表达与肿瘤的发生、分期、有无淋巴结转移相关。γ-syn基因(SNCG)异常调节发生在转录水平,与SNCG低甲基化有关。γ-syn异常表达危害正常有丝分裂监控点,使细胞通过非整倍体持续增殖,还可抑制半胱天冬酶活性,阻断凋亡应答;可通过MAPK途径,使MMP基因表达增加,提高MMP2活性和水平,促进肿瘤转移。γ-syn是潜在肿瘤生物标志,用基因调控技术抑制肿瘤转移复发和针对γ-syn的分子靶向药物研究正在进行。

γ-syn is one of the synuclein family, mainly localizes to the cell bodies and axons of neurons. The abnormal expression of this protein may be linked to the process of tumorigenesis, stage-specific of tumors and lymph node invasion. The transcriptional deregulation that results in SNCG in cancer cells induces SNCG expression through demethylation. The ectopic expression of γ-syn disrupts mitotic check point and allows cells to continue progression in aneuploidy, and inhibits caspase activity to disrupt the apop- totic response ; while it results in overexpression of MMP gene through MAPK signaling pathways promote cancer cell metastasis. γ-syn is proving to be a potential biomarker in tumor, studies have been carried out to explore the methods of suppressing cancer metastasis and recurrence by gene control and γ-syn targeting medince.