肿瘤相关循环内皮细胞的分类标志物及其功能研究进展

Recent Progress in Classification, Markers and Function of Tumor-related Circulating Endothelial Cells

经典肿瘤新生血管的形成主要包括血管生成(angiogenesis)和血管发生(vasculogenesis)、均依赖循环内皮细胞(circulating endothelial cells,CECs)的增殖、迁移、黏附而形成管腔。CECs不仅与血管新生和肿瘤生长、播散有关,还可能作为抗血管生成药物的靶点和反映疗效的标志物。循环内皮细胞膜上可表达多种表面分子,在从幼稚到成熟及活化过程要经历不同的阶段,而不同阶段细胞表达的表面分子有所不同。各表面分子在肿瘤血管新生过程中发挥重要作用。监测可靠的分子标志物量化CECs尤其是活化血管内皮细胞(activated circulating vascularendothelial cells,aCECs),来判定肿瘤新生血管和血管靶向治疗的疗效具有重要意义且已成为临床上的迫切需要。本文就肿瘤相关循环内皮细胞的分类、标志物及其功能做一综述。

Two major processes by which tumor blood vessels are developed and remodeled are based on the proliferation, migration, and adhesion of circulating endothelial cells （CECs）. CECs therefore contribute to tumor neovasculogenesis and possibly to the progression and metastasis of tumors. CECs are possible targets for antiangiogenic therapy and predictors of treatment efficacy. In this review, we discuss the classification, markers and function of tumor-related CECs.