双相障碍患者与正常人血浆孤啡肽水平的对照研究

Plasma levels of nociceptin/orphanin FQ in patients with bipolar disorders and health adults

目的探讨血浆孤啡肽（OFQ）水平与双相障碍的关系，为双相障碍的发病机制、诊断等寻找新的生物学指标。方法筛选47例双相障碍患者（抑郁组21例、躁狂组26例）和31名正常人，应用放射免疫（RIA）法分别测定其血浆OFQ浓度，比较病例组与对照组血浆OFQ水平，病例组OFQ含量与各量表总分的相关性。结果（1）抑郁组OFQ水平高于对照组（t=5．28，P〈0．01）；躁狂组OFQ水平低于对照组（t=-2．47，P〈0．05）。差异均具有统计学意义。（2）抑郁组OFQ含量与HAMD、MADRS总分呈显著正相关（r=0．607，P〈0．01；r=0．541，P〈0．05）；躁狂组OFQ含量与BRMS总分呈显著负相关（r=-0．750，P〈0．01）。结论血浆OFQ水平的变化可能参与了双相障碍的发生机制并可能反映病情的严重程度，为临床上寻找双相障碍的客观诊断依据及其判断疾病严重程度提供了可能的新的生物学指标。

Objective To investigate the plasma levels of nociceptin/orphanin FQ （OGQ） in patients with bipolar depression and bipolar mania and to analyze the relationship of plasma OFQ to bipolar disorders. Methods Peripheral blood samples were collected from 21 patients with bipolar Ⅱ depression （BD group）, 26 patients with bipolar Ⅰ mania （BM group）, and 31 health adults （control group）. The concentrations of plasma OFQ were measured by radioimmunoassay （ RIA ）. The psychological status was examined by Hamilton Depression Scale （HAMD）, Bech-Rafaelsen Mania Rating Scale （BRMS）, and Montgomery and Asberg Depression Rating Scale （MADRS）. Results The plasma OFQ level of the BD group was （20±4 ） rig/L, signifgcantly higher than that of the control group [ （ 14 ± 5 ） ng/L, t = 5.28 ,P 〈 0.01 ], and the OFQ level of the BM group was （ 11 ± 3 ） ng/L, significantly lower than that of the control group （t = -2.47 ,P 〈0.05 ）. There were not significant differences in the plasma OFQ between the males and females in all groups （ all P 〉 0.05 ）. In the BD group the plasma OFQ level was significantly positively correlated with HAMD and MADRS scoreds （ r = 0. 607, P 〈 0.01 ; r = 0. 541, P 〈 0.05 ）. In the BM group the plasma OFQ level was significantly negatively correlated with the BRM score （r = -0.750,P 〈 0.01 ）. Conclusion The changes of plasma OFQ level may play a role in the pathogenesis of bipolar disorder and indicate the severity of disease. Plasma OFQ may be a new biological parameter of bipolar disorder.