老年慢性心力衰竭患者血尿酸和肿瘤坏死因子-α的变化及临床意义

Clinical significance and changes of serum uric acid and TNF-α levels in elder patients with chronic heart failure

目的:探讨慢性心力衰竭(CHF)患者血尿酸和肿瘤坏死因子-α(TNF-α)的变化及临床意义。方法:选择72例CHF患者为研究组及30例健康人为对照组,测定其血尿酸及TNF-α水平,同时应用超声心动图测定LVEF。结果:①CHF患者血尿酸及TNF-α明显高于对照组(P<0.05或P<0.01);并且随着心功能NYHA分级程度的加重,血尿酸和TNF-α水平呈进行性升高。②血尿酸与TNF-α浓度呈正相关(r=0.382,P<0.01)与LVEF呈负相关(r=-0.538,P<0.01)。结论:血尿酸和TNF-α在CHF患者中增高,与心功能分级相关,且与炎症因子密切相关。

Objective： To investigate the changes and clinical significance of serum uric acid and TNF-α in the patients with chronic heart failure. Methods： 72 cases of CHF were taken as study group and 30 cases of normal cardiac function were taken as control group. Serum uric acid and TNF-α levels were determined, meanwhile LVEF （left ventricular ejection fraction） were determined by echocardiography. Results： ①Serum uric acid levels and TNF-α were significantly higher in patients with CHF than those of controls （P〈0.05 or P〈0.01）. Serum uric acid and TNF-α levels progressively elevated with severe degree of cardiac function classification in NYHA. ②Serum uric acid and TNF-α levels had positive correlation （r= 0.382, P〈0.01）, and both had negative correlation with LVEF （r=-0.538, P〈0.01）. Conclusion： Serum uric acid and TNF-α levels are significantly higher in the patients with CHF, both are correlated with cardiac function classification and have strong correlation with inflammation factors.