大剂量丙种球蛋白联合地塞米松治疗重度ITP疗效观察

Clinical of combining high dosage gamma globulin with Dexamethasone in severe ITP patients

目的:评价大剂量丙种球蛋白联合地塞米松治疗特发性血小板减少性紫癜(ITP)的疗效。方法:将50例患者随机分为两组,联合组静滴丙种球蛋白400mg/(kg·d),连用5d,同时静滴地塞米松1.5mg/(kg·d),连用5d,第5天起口服强的松2mg/(kg·d)。地塞米松组静滴地塞米松1.5mg/(kg·d),连用5d,第5天起口服强的松2mg/(kg·d)。结果:联合组、地塞米松组使血小板计数(PLT)≥50×109/L的时间分别为(2.5±1.1)d,(5.1±1.2)d;PLT≥100×109/L的时间分别为(4.4±1.3)d,(7.8±1.5)d;达峰值时间分别为(6.9±1.2)d,(13.6±1.6)d,PLT的峰值分别为(310±102)×109/L,(160±62)×109/L。结论:大剂量丙种球蛋白联合地塞米松治疗重度ITP效果显著。

Objective： To evaluate high dosage gamma globulin with Dexamethasone in ITP patients. Methods： 50 patients were randomly divided into two groups. Joint group were given gamma globulin 400 mg/（kg.d） for 5 days, while intravenous Dexamethasone 1.5 mg/（kg.d） for 5 days, the first 5 days of oral Prednisolone 2 mg/（kg.d）. Dexamethasone group were given Dexamethasone 1.5 mg/（kg.d） for 5 days, the first 5 days of oral Prednisolone 2 mg/（kg.d）. Results： The time of PLT ≥50×10^9/L in the joint group and Dexamethasone group were （2.5_＋1.1） days, （5.1±1.2） days; The time of PLT ≥ 100 ×10^9/L were （4.4±1.3） days, （7.8±1.5） days; peak days were （6.9±1.2） days, （13.6±1.6） days, PLT peak were （310±102）×10^9/L, （160±62）×10^9/L. Conclusion： The high dose gamma globulin combined with Dexamethasone in the treatment of severe ITP has significant effect.