中西医结合治疗原发性胆汁性肝硬化25例临床观察

Clinical Observation of Integrative Chinese and Western Medicine in Treatment of 25 Cases of Primary Biliary Cirrhosis

目的观察中西医结合治疗原发性胆汁性肝硬化(PBC)的临床疗效。方法将25例PBC患者根据中医辨证分型分为肝郁脾虚、脾胃气虚、湿热瘀血、肝肾阴虚4种证型,不同证型采用不同的方剂辨证加减治疗,同时应用西药熊去氧胆酸。观察患者治疗后临床疗效及肝功能各指标情况。结果25例患者经治疗后显效9例,有效10例,总有效率为76%。肝功能各项指标(ALT、AST、ALP、GGT、TBiL)和IgM均有明显改善,与治疗前相比有显著性差异(P<0.05,P<0.01)。结论中西医结合治疗PBC具有较好的临床疗效,值得推广。

Objective To observe the clinical efficacy on primary biliary cirrhosis（PBC）treated with integrative Chinese and western medicine.Methods 25 cases of PBC were divided into 4 syndromes in light of syndrome differentiation of Chinese medicine,named liver stagnation and spleen deficiency,qi deficiency of the spleen and stomach,damp heat and blood stasis,and yin deficiency of the liver and kidney;different formulas were modified for different syndromes.Additionally,ursodeoxycholic acid was applied.It was to observe clinical efficacy after treatment and various indexes of liver function in two groups.Results Of 25 cases,9 cases were effective markedly,10 cases effective;the total effective rate was 76%.Every index of liver function（ALT,AST,ALP,GGT and TBiL）and IgM were all improved apparently,which indicated significant differences compared with those before treatment（P〈0.05,P〈0.01）.Conclusion Integrative Chinese and western medicine achieves good clinical efficacy on PBC and deserves to be promoted.