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胃癌组织中前列腺素E_2受体的表达及意义 被引量：4

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摘要 目的探讨前列腺素E2(PGE2)受体(EP)在胃癌组织中的表达情况。方法用荧光定量PCR(FQ-PCR)法测定42例胃癌组织及其周围正常组织中EP的4种亚型(EP1、EP2、EP3、EP4)mRNA。结果胃癌组织中EP1mRNA表达量为0.181±0.112,高于正常胃组织的0.064±0.043(P<0.05);EP2 mRNA的表达量为0.126±0.082,与正常胃组织的0.158±0.077相近(P>0.05);EP3 mRNA和EP4 mRNA的表达量分别为0.044±0.021和0.093±0.035,均低于正常胃组织的0.117±0.085和0.162±0.068(P<0.05)。结论EP1的高表达和EP3和EP4的表达下调可能参与了胃癌的发生。
作者 蔺武 刘心娟 吴静 林香春 魏南 姜国俊
机构地区 北京世纪坛医院
出处 《山东医药》 CAS 北大核心 2009年第14期71-72,共2页 Shandong Medical Journal
关键词 前列腺素E受体 胃肿瘤
分类号 R735.2 [医药卫生—肿瘤]
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参考文献13

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二级参考文献19

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共引文献13

同被引文献42

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二级引证文献6

山东医药
2009年 第14期

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