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口腔鳞状细胞癌组织中HSP90的表达及意义 被引量:1

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摘要 目的探讨热休克蛋白90(HSP90)在口腔鳞状细胞癌(OSCC)中的表达及其与OSCC临床病理指标的关系。方法采用免疫组化法检测48例OSCC和26例正常口腔黏膜组织中HSP90的表达情况。结果正常口腔黏膜的HSP90阳性表达率为34.61%(9/26),显著低于OSCC中的77.08%(37/48,P(0.05)。患者HSP90的表达与患者年龄、性别无关(P>0.05),而与OSCC分化程度有关。结论随OSCC分化程度的降低,HSP90表达越明显。HSP90可能在口腔癌的发生发展中发挥重要作用。
机构地区 中国解放军第
出处 《山东医药》 CAS 北大核心 2009年第14期83-84,共2页 Shandong Medical Journal
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