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糖尿病视网膜病变患者玻璃体中AGE、VEGF的表达及意义 被引量：1

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摘要 目的探讨糖尿病视网膜病变玻璃体中糖基化终产物(AGEs)和血管内皮生长因子(VEGF)水平与糖尿病视网膜病变的关系。方法采用ELISA法测定41例糖尿病视网膜病变患者(A组)玻璃体中的AGEs和VEGF,并与28例非糖尿病(B组)进行对照;A组选20例和B组选18例,用黄嘌呤氧化酶法测定玻璃体内超氧化物歧化酶(SOD),用改良Witko-Sarsat法测定血清晚期氧化蛋白产物(AOPP)。结果A组玻璃体内AGEs和VEGF水平明显高于B组(P<0.01),AGEs与VEGF呈正相关(r=0.64,P<0.001),A组玻璃体内的抗氧化能力较B组明显降低(P<0.01)。结论糖尿病视网膜病变的发生与其玻璃体内AGEs和抗氧化能力的降低有关,其作用是通过VEGF而产生的;玻璃体内AGEs和VEGF水平越高,其抗氧化能力越低。
作者 胡磊 马伟建 李艳春 姜慧 王玉
机构地区 泰山医学院附属医院 济南市第二人民医院
出处 《山东医药》 CAS 北大核心 2009年第14期87-88,共2页 Shandong Medical Journal
关键词 糖尿病 视网膜病变 玻璃体糖基化终产物 血管内皮生长因子
分类号 R776 [医药卫生—眼科]
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参考文献12

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共引文献2

同被引文献24

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山东医药
2009年 第14期

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