甲氨蝶呤配伍米非司酮治疗输卵管妊娠47例

Observation on Curative Effect of Mifepristone Combined Methotrexate on Tubal Pregnancy

目的观察甲氨蝶呤配伍米非司酮用于输卵管妊娠保守治疗的疗效。方法将96例确诊为输卵管妊娠的住院患者随机分为2组,A组(47例)使用甲氨蝶呤0.1mg/(kg·d)臀部肌肉注射,连续5d,第2天加用米非司酮50mg,每12h1次,空腹口服,连续3d;B组(49例)单用甲氨蝶呤。结果治疗成功A组42例(89.36%),B组39例(79.59%);A组住院时间、血β-HCG下降大于15%的时间及转阴时间均明显短于B组(P<0.01)。结论甲氨蝶呤配伍米非司酮用于输卵管妊娠保守治疗效果优于单用甲氨蝶呤。

Objective To observe the curative effeect of methotrexate combined mifepristone for the conservative treatment of tubal pregnancy. Methods 96 cases of tubal pregnancy were randomly divided into 2 groups. Group A（47cases） was given methotrexate 0.1 mg/（kg, d） by intramuscular injection for 5 d, on 2 d adding oral Mifepristone 50 mg, once each 12 h, for 3 d. Group B（49 cases） was given only methotrexate 0. 1 mg/（kg·d） by intramuscular injection for 5 d. During treatment period, abdominal pain, vaginal bleeding, blood pressure and pulse were observed. Detection of blood β- HCG and B- ultrasound examination were regularly performed. Results 42 cases in group A were successful, accounting for 89.36%, 39 cases in B group accounting for 79.59%. Hospitalization time, blood β- HCG decrease 〉 15% and β- HCG turning- negative time in group A were significantly shorter than those in the group B（P〈0.01）. Conclusion Mifepristone combined methotrexate for tubal pregnancy conservative treatment is better than methotrexate alone.