不同冠状动脉狭窄程度时血浆8-异前列腺素F2α水平变化及其意义

The clinical significance of serum 8-iso-PGF2α in different degree of coronary artery stenosis

目的探讨冠心病（CAD）患者血浆8-异前列腺素F2α（8-iso--PGF2α）水平与冠状动脉狭窄之间的关系。方法选取拟诊冠心病患者87例，行冠状动脉造影检查，按照造影结果分为非CAD组（狭窄〈50％）30例，狭窄50％～70％组22例，狭窄〉70％组35例。用酶联免疫吸附法（ELISA）检测血浆8-iso-PGF2α水平。结果非CAD组、狭窄50％～70％组及狭窄〉70％组血浆8-iso—PGF2α水平逐步升高，各组间差异均具有统计学意义（P〈0．05）。结论血浆8-iso—PGF2α水平与冠状动脉狭窄程度有关，可反映心肌缺血情况。

Objective To explore the relationship between 8-iso-PGF2α, level in serum and the extent of coronary artery stenosis. Methods 87 eases who received conventional coronary angiography（CAG） were enrolled in this study. All cases were divide into three groups by CAG： coronary artery stenosis〈50% group（n=30）, coronary artery stenosis 50%-70% group （n=22）, coronary artery stenosis〉70% group （n=35）. ELISA method was used to detect the 8-iso-PGF2α level in serum. Results 8-iso-PGF2α level in serum increased with the increasing degree of coronary artery stenosi （P〈0.05）. Conclusion The 8-iso-PGF2α level in serium is concerned with the extent of coronary artery stenosis, which can reflect myocardial isehemia.