酚妥拉明、硫酸镁与法莫替丁联合治疗重度支气管哮喘63例疗效观察

Clinical study on the efficacy of phentolamine、magnesium sulfate and famotidine in treatment of 63 severe asthma patients

目的观察酚妥拉明、硫酸镁加法莫替丁注射液治疗重度支气管哮喘的疗效。方法选择重度支气管哮喘急性发作患者87例,随机分成两组。对照组24例予西医常规治疗,治疗组63例在对照组治疗基础上加用酚妥拉明10mg、硫酸镁2.5g、法莫替丁40mg静滴。观察两组疗效及治疗前后肺活量(VC)、用力肺活量(FVC)和1s用力呼气量(FEV1)的变化。结果两组总有效率分别为96.8%和79.2%,治疗组疗效优于对照组(P(0.01)。治疗组治疗后肺功能明显改善,治疗前后比较VC分别为(1.79±0.39)L和(2.51±0.65)L,(P(0.01);FVC分别为(1.91±0.51)L和(2.41±0.66)L,(P(0.01);FEV1分别为(0.93±0.75)L和(1.42±0.39)L,(P(0.01)。与对照组相比有显著统计学意义(P<0.01)。结论在常规疗法的基础上加用酚妥拉明、硫酸镁和法莫替丁注射液可提高治疗重度支气管哮喘的疗效。

Objective To observe the effect of phentolamine, magnesium sulfate combined with famotidine injection on severe asthma. Methods 87 eases with severe asthma during acute seizure phase were randomly divided into two groups. The control group（ n = 24） was treated with conventional therapy of western medieine. Intervention group（n=63） were treated with phentolamine injeetion 10mg, magnesium sulfate injection 2.5g,famotidine injection 40mg infused intravenously except for the conventional therapy of western medicine which used for the control group. The curative efficacy and the variations of vital capacity（VC） , forced vital capacity （FVC）, and forced expiratory, volume（ FEV1 ） were observed before and after the therapy. Results The total effective rates in two groups were 96. 8% and 79. 2% , respectively. The curative efficacy in intervention group was significantly superior to that in eontrol group（ P 〈 0. 01 ）. After therapy the pulmonary functions were significantly improved in the inter- vention group. The VC before and after treatment were （ 1.79 - 0. 39） L and （2. 51 ± 0. 65 ） L（ P 〈 0. 01 ）, respectively, for FVC were（ 1.91 ± 0. 51 ） L and （ 2. 41 ± 0. 66） L （ P 〈 0. 01 ）, respectively, for FEVI were （ 0. 93 ±0. 75 ） L and （ 1.42± 0.39） L （ P 〈 0. 01 ） , respectively. Compared with the control group, they were significantly different （ P 〈 0.01 ）. Conclusion In the base of conventional therapy, combined with phentolamine, magnesium sulfate and famotidine injection can improve the treatment of severe bronchial asthma.