利培酮与氟哌啶醇治疗酒精所致精神障碍对照研究

Comparative study of risperidone and haloperidal in the treatment of mental disorders due to use of alcohol

目的探讨利培酮治疗酒精所致精神障碍的疗效及安全性。方法将符合条件的72例酒精所致精神障碍患者随机分成利培酮组36例和氟哌啶醇组36例,进行8周系统治疗,采用PANSS、TESS量表分别评定疗效及不良反应。结果治疗后两组PANSS总分均明显下降,两组间差异无统计学意义(P>0.05),治疗第4、第8周阴性症状分差异有统计学意义(P<0.05),利培酮组有效率为88.9%,显效率为58.3%,与氟哌啶醇组疗效相当,但阴性症状疗效优于氟哌啶醇组。结论利培酮治疗酒精所致精神障碍对改善阴性症状更有效,疗效较好,不良反应较少,能提高社会功能,促进患者康复。

Objective To investigate the clinical effects and side effects of risperidone for treating mental disorders due to use of alcohol. Methods A total of 72 patients were divided into risperidone group （ n = 36） and haloperidal group（n =36）. After treatment of 8 weeks, the clinical effects and side effects were evaluated with PANSS and TESS Scale. Results After treatment, the scores of PANSS in both groups decreased ,but there were no statistical difference between two groups （ P 〉 0. 05 ）. Significant difference was found between two groups of scale about negative symptoms after the treatment of 4 and 8 weeks （ P 〈 0.05 ）. Curative effects of risperidone was similar to that of haloperidol, and it＇s effective rate and the significant effective rate were 88.9% and 58.3% respectively. But risperidone group was better in treating negative syndromes than haloperidal group. Conclusion Rispefidone has better effects and social functions than haloperidal in the treatment of negative symptoms with fewer side effects for treating mental disorders due to use of alcohol