摘要
目的研究血管转换酶抑制剂(ACEI)治疗心力衰竭(CHF)的临床效果。方法将96例充血性心力衰竭患者随机分成治疗组和对照组,治疗组(n=65)在常规治疗基础上加用血管转换酶抑制剂,从小剂量开始逐步达到"靶剂量",对照组(n=31)仅给予常规治疗(强心、利尿、扩血管)。两组服药前后检查心率、6min步行测验、血压、LVDD、LVEF、心功能,并进行比较。随访3年。结果ACEI治疗CHF后心率减慢,血压下降,6min步行距离增加,治疗组临床指标改善明显,心功能改善总有效率达89.2%,而对照组仅67.7%,两组比较具有统计学意义(P<0.01)。结论ACEI治疗CHF可改善心功能,提高生存率和生活质量,防止和延缓心肌重塑的发展,从而降低心力衰竭的死亡率,值得推广。
Objective To study the clinical effect of angiotensin - converting enzyme inhibitor (ACEI) to treat congestive heart failure (CHF). Methods Chose 96 cases the congestive heart failure were randomly divided into treatment and control groups. The treatment groups ( n = 65 ) used ACEI on routing treatment base. Dose from low to ' target dose' step to step. In the control groups ( n = 31 ) were given only routine treatment ( Cardiotoni, Diuretic and Vasodioctive). Test heart rate, Blood pressure, the distance for 6 minutes walking test, LVDD, LVEF and heart function grade. Then compared the changes before and after treatment and assessed the clinical effects. Patients were followed up for 3 years. Results After ACEI treated CHF, the heart rate decreased, blood pressure lower, 6 - minute walking distance increase. The heart function improved ob^iously, the valid rate reached 89.2% , the control groups only 67.7%, the statisticalogy signitieantly compared on two groups( p 〈0.01 ). Conclusion ACEI treat CHF improves the heart function, survival rate and living quality. The cardie remodeling developing were prevent and postpone. So dead rate and admission reduced.
出处
《海南医学》
CAS
2009年第4期42-44,共3页
Hainan Medical Journal
关键词
血管转换酸抑制剂
心力衰竭
治疗
Angiotensin - converting enzyme inhibitor ( ACEI )
Congestive heart failure (CHF)
Treat-ment