慢性乙型肝炎患者凝血功能指标检测的临床研究

Clinical significance of assaying APTT,PT,TT,and FIB in patients with chronic hepatltis B

目的研究慢性乙型肝炎患者凝血指标改变的临床意义。方法采用法国STA-GO全自动凝血分析仪检测98例慢性乙型肝炎患者的部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）和纤维蛋白原（FIB）,并与60例对照组进行比较分析。结果慢性乙型肝炎患者存在不同程度凝血功能障碍,APIT、PT、TT、FIB水平与对照组比较,有显著性差异（P〈0.05）。结论慢性乙型肝炎患者凝血指标的变化,能够反映患者肝脏受损程度,对肝病病情诊断、治疗和预后评估有重要意义。

Objective To analyze the variation of the coagulation state and its clinical significance in the patients with hepati- tis B. Methods 98 venous blood samples from the patients with hepatitis B were examined for plasma activated partial thromboplastic time （ AFFI＇）, prothrombin time （ PT）, and fibrinogen （FIB） using STA Compact automatic coagulation analyzer and compared with the results from normal subjects as controls. Results The APTT, PT,TT, and FIB values in the groups of hepatocirrhosis and chronic hepa- titis B patients showed clinically significant differences from those in the healthy controls （ P 〈 0.05 ）. Conclusions Changes in APTT, PT, TT, and FIB reflect the damage of liver in the chronic type B hepatitis patients . And they have important significance in evaluation of therapy and prognosis.