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髓过氧化物酶在心血管疾病中的作用 被引量：4

Effect of Myeloperoxidace in Cardiovascular Disease
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摘要 髓过氧化物酶是一种主要由中性粒细胞分泌的白细胞酶,在心血管疾病的发生发展中,包括发病初期、发展及动脉粥样硬化急性复合病变期,MPO及其介导的炎症途径促进了动脉粥样硬化的形成,因此MPO可以作为心肌损伤、治疗和预后的标志物。 Myeloperoxidace （Mpo） is a leukocyte derived enzyme that catalyzes the formation of a number of reactive oxidant species. Mpo catalyzed reaction has been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation and acute complication phases of the atherosclerotic process. As a result, Mpo and its downstream inflammatory pathways represent targets for myocardial injury, therapeutic and prognosis.
作者 王天菊 卿之驹
机构地区 中南大学湘雅二医院检验科
出处 《实用预防医学》 CAS 2009年第2期623-625,共3页 Practical Preventive Medicine
关键词 髓过氧化物酶 心血管疾病 低密度脂蛋白 高密度脂蛋白 内皮细胞功能障碍 不稳定斑块 一氧化氮 Myeloperoxidace Oardiovascular disease Low density lipoprotein High density lipoprotein Endothelial cell dysfunction Unstable plaque Nitric oxide
分类号 R322.1 [医药卫生—人体解剖和组织胚胎学]
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参考文献28

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二级参考文献64

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共引文献34

同被引文献41

  • 1李惠,包宗明.髓过氧化物酶及其多态性与冠状动脉疾病的研究进展[J].中国心血管病研究,2007,5(1):70-72. 被引量：13
  • 2贾克刚,刘军锋,马明坤,韩雪晶,柴俊岩.血清髓过氧化物酶和高敏C反应蛋白与冠状动脉粥样硬化的相关性研究[J].检验医学,2007,22(2):179-181. 被引量：5
  • 3苏淑红,刘志强,严松彪,陈晖.髓过氧化物酶与急性冠脉综合征[J].北京医学,2007,29(4):235-237. 被引量：6
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引证文献4

二级引证文献10

实用预防医学
2009年 第2期

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