缺氧诱导因子-1α在颈动脉粥样硬化发病机制中的研究

Study on HIF-1α in Pathogenesis of Carotid Atherosclerosis

新生血管生成和炎症浸润是颈动脉粥样硬化不稳定斑块的重要特点,其产生的分子机制尚不完全清楚。缺氧诱导因子-1是一个能在缺氧状态下发挥活性的转录因子。在颈动脉粥样硬化病变中,缺氧诱导因子-1通过α活性亚单位调控多种靶基因表达而促进新生血管生成、促进炎症反应和平滑肌细胞迁移增殖导致病变进展。

Angiogenesis and inflammation are the important features in atherosclerotic plaque destabilization. The mechanisms of plaque angiogenesis and inflammation are largely unknown. The transcription factor hypoxia inducible factorlalpha （HIF- 1α） is a key regulator of angiogenesis and is also involved in inflammatory reactions. HIF pathway is associated with progression and angiogenesis of human atherosclerosis.