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食管癌高发区贲门癌与基质金属蛋白酶-2及其组织抑制剂-2基因多态性的关联研究 被引量：2

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摘要 河北省涉县是我国上消化道肿瘤（UGIC）的高发地区。近年来的流行病学研究显示，该地区的食管癌和胃癌的发病率呈下降趋势，贲门癌则呈明显上升趋势。国家肿瘤登记中心最新数据，2000--2004年男、女贲门癌的发病率分别为69．9／10万和41．5／10万，贲门癌已成为影响当地人民身体健康的重要疾病。但迄今，有关贲门癌的发病机制尚不明确。本研究拟采用病例-对照研究，探讨基质金属蛋白酶-2（matrix metalloproteinases-2，MMP-2）和其组织抑制剂-2（tissue inhibitor of metalloproteinase-2，TIMP-2）基因启动子区单核苷酸多态性（single nucleotide polymorphism，SNP）与河北省涉县人群贲门癌遗传易感性的关系，为贲门癌的早期筛查提供可能的分子标志物。
作者 孙东兰 段亚男 张晓娟 周荣秒 王娜 陈志峰 李琰
机构地区 河北医科大学第四医院肿瘤研究所
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2009年第4期342-344,共3页 Chinese Journal of Preventive Medicine
关键词 基质金属蛋白酶-2 食管癌高发区 组织抑制剂 贲门癌 基因多态性 抑制剂-2 病例-对照研究 单核苷酸多态性
分类号 R686 [医药卫生—骨科学]
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参考文献6

  • 1Holla LI, Fassmann A, Vasku A, et al. Genetic variations in the human gelatinase A ( matrix metalloproteinase-2 ) promoter are not associated with susceptibility to, and severity of, chronic periodontitis. J Periodonto, 2005,76 : 1056-1060.
  • 2Rollin J, Regina S, Vourc'h P, et al. Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer. Lung Cancer, 2007, 56: 273 -280.
  • 3Miao X, Yu C, Tan W, et al. A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. Cancer Res, 2003, 63:3987-3990.
  • 4Zhou Y, Yu C, Miao X, et al. Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis,2005,26 : 1117-1121.
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同被引文献22

  • 1张雪梅,缪小平,熊萍,于春媛,谭文,曲世宁,孙瞳,周翊峰,林东昕.基质金属蛋白酶(MMP)-2和-9功能性单核苷酸多态与胃癌[J].癌症,2004,23(11):1233-1237. 被引量：9
  • 2张立玮,温登瑰,王士杰,李英赛,于卫芳,王晓玲,王俊和,李素平,李永伟,王顺平,尔立绵,丛庆文,马彩芬.食管癌高发区贲门癌、胃癌流行强度分析及其对内镜筛查的启示[J].肿瘤防治研究,2005,32(12):792-795. 被引量：34
  • 3Chambers AF,Matrisian LM. Changing views of the role of matrix metalloproteinase in metastasis[J].{H}JOURNAL OF THE NATIONAL CANCER INSTITUTE,1997,(17):1260-1270.
  • 4Egeblad M,Werb Z. New functions for the matrix metalloproteinases in cancer progression[J].{H}Nature Reviews Cancer,2002,(3):161-174.
  • 5Price S J,Greaves DR,Watkins H. Identification of novel,functional genetic variants in the human matrix metalloproteinase-2 gene:role of Sp1 in allele-specific transcriptional regulation[J].{H}Journal of Biological Chemistry,2001,(10):7549-7558.
  • 6De Clerck YA,Darville MI,Eeckhout Y. Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (T IMP-2)[J].{H}GENE,1994,(2):185-191.
  • 7Zhou Y,Yu C,Miao X. Substantial reduction in risk of breast Cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2genes[J].{H}CARCINOGENESIS,2004,(3):399-404.
  • 8Yu C,Pan K,Xing D. Correlation between a single nucleotide polymorphism in the matrix metalloproteinase-2 promoter and risk of lung Cancer[J].{H}CANCER RESEARCH,2002,(22):6430-6433.
  • 9Justenhoven C,Hamann U,Pesch B. ERCC2 genotypes and a corresponding haplotype are linked with breast Cancer risk in a German population[J].{H}Cancer Epidemiology Biomarkers & Prevention,2004,(12):2059-2064.
  • 10Gialeli C,Theocharis AD,Karamanos NK. Roles of matrix metalloproteinases in Cancer progression and their pharmacological targeting[J].{H}FEBS JOURNAL,2011,(1):16-27.

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中华预防医学杂志
2009年 第4期

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