急性冠脉综合征患者血清抵抗素和脂联素水平的研究

Study of Serum Resistin and Adiponectin Levels in Patients with Acute Coronary Syndrome

【目的】研究急性冠脉综合征（ACS）患者血清抵抗素和脂联素水平的变化及其病理生理意义。【方法】酶联免疫法测定76例ACS患者的血清抵抗素、脂联素及超敏C反应蛋白水平，其中急性心肌梗死组46例，不稳定性心绞痛组30例，并选取24例健康体检者为正常对照组。【结果】与正常对照组相比，ACS患者血清抵抗素、超敏C反应蛋白水平升高（均P〈0．01），脂联素水平降低（P〈0．01）；另外与不稳定性心绞痛组相比较，急性心肌梗死组血清抵抗素（P〈0．05）、超敏C反应蛋白（P〈0．01）和脂联素（P〈0．01）水平差异均有统计学意义。在各指标之间的相关性分析中，血清抵抗素与超敏C反应蛋白（r=0．536，P〈0．01）呈正相关，脂联素与超敏C反应蛋白（r=-0．446，P〈0．01）呈负相关。[结论]ACS患者血清抵抗素水平升高，脂联素水平降低，与超敏C反应蛋白具有相关性，提示了脂肪细胞分泌的血清抵抗素和脂联素与动脉粥样硬化的形成和ACS的发病有关。

[Objective] To explore the changes of serum resistin and adiponectin levels in patients with acute coronary syndrome and their possible pathologic roles. [Methods] Serum resistin, adiponectin and highsensitive C-reactive protein levels were measured by using enzyme-linked immunosorbent assay in 76 patients with acute coronary syndrome （46 acute myocardial infarction and 30 unstable angina pectoris） and 24 normal control subjects. [Results] Compared with normal control, patients with acute coronary syndrome had higher concentrations of serum resistin and high-sensitive C-reactive protein（ P 〈0.01） ,and lower concentrations of serum adiponectin（ 19〈0.01）. Moreover, there were statistical difference in serum resistin （ P d0.05）, adiponectin（ P〈0. 01） and high-sensitive C reactive protein （P 〈0. 01） between acute myocardial infarction group and unstable angina pectoris group. The concentrations of serum resistin was positively correlated with that of hs-CRP（r= 0. 536, P 〈0.01 ）. The concentrations of serum adiponectin was negatively correlated with that of hs-CRP（r= -0. 446, P 〈0.01）. [Conclusion]Serum resistin concentrations are significant higher but adiponectin are lower in patients with acute coronary syndrome. Both resistin and adiponectin are significantly correlated to hs-CRP, therefore they may be involved in the development of atherosclerosis and acute coronary syndrome.