摘要
【目的】探讨血液灌注+血液透析与其它血液净化方式对血清β2-微球蛋白(β2MG)和甲状旁腺激素(PTH)的清除效果。【方法】将72例维持性血液透析患者随机分为三组:血液灌流+血液透析(HDP)组、血液透析(HD)组和血液透析滤过(HDF)组,比较三组单次治疗对血清β2--MG和PTH的清除率。【结果】①HD组、HDF组和HDP组均能有效清除血清尿素氮(BUN)、肌酐(Scr)和血磷(P〈0.01)。②HDP组与HDF组治疗前后血清β2-MG和PTH均显著下降(P〈0.01),HD组治疗前后血清β2-MG和PTH均无显著下降(P〉0.05);③HDP组与HDF组对β2-MG和PTH的清除率比较差异无显著性(P〉0.05),此两组的清除率与HD组比较差异均有显著性(P〈0.01)。【结论】HDP与HDF可有效清除β2-MG及PTH;HD不能有效清除β2-MG及PTH。
[Objective] To compare the clearance effects of different blood purification methods on β2 microglobulin and parathyroid hormone (PTH) levels in patients on maintenance hemodialysis(HD). [Methods] Seventy two patients on maintenance hemodialysis were randomly divided into hemodiafihration group (HDF) , hemoperfusion plus hemodialysis group(HDP) and hemodialysis group(HD). Serum PTH and β2-microglobulin levels were observed before and after single treatment. [Results] In HDF and HDP group, PTH and β2-microglobulin were decreased significantly ( P 〈0.05). The difference between HDF and HDP was not significant ( P 〉0.05). After HD treatment, serum PTH and β2-microglobulin were not decreased ( P 〉0.05). [Conclusion] Hemodiafiltration or hemoperfusion plus hemodialysis can safely and effectively clear serum β2 microglobulin and PTH, while hemodialysis can not effect the level of serum β2-microglobulin and PTH.
出处
《医学临床研究》
CAS
2009年第3期477-478,481,共3页
Journal of Clinical Research