5-溴水杨醛-O-β-D-葡萄糖苷的合成与结构表征

Study on Synthesis of 5-Bromosalicylaldehyde-O-β-D-glucoside and Its Strucure Characterization

为得到抗菌活性优异的化合物,通过首先分别合成5-溴水杨醛和2,3,4,6-O-四乙酰基-α-D-溴代葡萄糖,随后经DMAP催化糖苷化和甲醇钠-甲醇碱性水解等反应步骤,成功合成5-溴水杨醛-O-β-D-葡萄糖苷。利用1H NMR,13C NMR,IR,GC-M S等对所合成的目标化合物及中间体进行了结构表征。

In order to obtaine compounds with good antibacterial activity, 5-bromosalicylaldehyde-O-β-D-glucoside was synthesized by the following process： 5-bromosalicylaldehyde and 2, 3, 4, 6-O-te- traacetyl-α-D-glucopyranosyl bromide were synthesized seperately and then followed by O-glycosylation with DMAP as a catalyst and hydrolysis in aqueous solution with CH3ONa-CH3OH. Structures of the target compound and intermediates were characterized by ^1H NMR,^13C NMR, IR and GC-MS.