胸腺切除术治疗重症肌无力22例报告

Thymusectomy in myasthenia gravis for 22 cases

目的探讨胸腺切除术治疗重症肌无力的方法及疗效。方法回顾性总结该院2003年3月～2007年8月收治的22例行胸腺切除术的重症肌无力患者。对其临床特点、病理分型、手术疗效等进行分析。结果22例患者胸腺增生者13例(59.1%),胸腺瘤者7例(31.8%),胸腺萎缩者2例(9.1%),正常胸腺者0例。按Monden标准评价疗效:缓解7例(31.8%),改善11例(50%),无变化4例(18.2%),恶化0例,总有效率为81.8%。结论重症肌无力与胸腺病变关系密切,有手术适应证患者手术治疗疗效肯定,应尽早手术。

[Objective] To study the therapetie effects of thymuseetomy in myasthenia gravis. [Methods] Summarize 22 cases of myasthenia gravis who underwent thymusectomy in the frith affiliated hospital of Sun Yat-sen University during Mar 2003 to Aug 2007, and analyze the clinical features, pathological typing and the therapetlc effects of them. [Result] Among these 22 cases, 13 patients had thymic hyperplasia （59.1%）, 7 patients had thymoma （31.8%）, 2 patients had thymus atrophy （9.1%）, none had normal thymus. According to Monden＂ standard, 7 patients got relived （31.8%）, 11 patients improved （50%）, 4 patients showed no change （18.2%）,and none deteriorated.The total effective rate of thymectomy was 81.8%. [Conclusion] Thymusectomy is one effective and safe therapy method in myasthenia gravis. It should be taken in the early stage of disease.