手性高效液相色谱法测定1-(6’-甲氧基萘)乙醇不对称氢酯基化反应

Determination of Enantiomer Excess Value for the Asymmetric Hydroesterification Reaction of 1-(6'-Methoxylnaphthyl)ethanol Using Chiral High PerformanceLiquid Chromatographic Method

在自制的硅基纤维素－三（３，５－二甲基苯基氨基甲酸酯）（ＣＤＭＰＣ）高效液相色谱手 性固定相上（ＨＰＬＣ－ＣＳＰ），优化了１－（６’－甲氧基萘）乙醇氢酯基化反应产物－萘普生甲酯手 性分离的条件，测定了相应的一系列不对称氢酯基化反应产物的对映体过剩值（ｅ．ｅ．值）。结 果表明，在ＣＤＭＰＣ－ＣＳＰ手性柱上用ＨＰＬＣ测定此类不对称催化反应的光学产率，评价催化 剂体系的手性选择性是一种非常理想的方法。

The chiral separation of the racemic naphthxen methyl ester on the cellulose tris (3,5-dimethylphenylcarbamate)chiral stationary phase prepared by us has been investigated. Under optimum conditions, the enantiomer excess value of the product, naphthxen methyl ester and asymmetric hydroestrification reaction is determined by HPLC with a direct injecting way after samples are diluted with the mobile phase. The results show that the method established is very ideal for evaluating the enantioselectivity of asymmetric catalytic reactions.