钾离子敏感试验与间质性膀胱炎PUF评分的相关性研究

Relationship of potassium sensitivity test and PUF in interstitial cystitis

目的探讨钾离子敏感试验（PST）与间质性膀胱炎（IC）盆腔疼痛和尿频、尿急症状（PUF）评分的相关性及意义。方法IC患者14例。女13例，男1例。平均年龄48岁。临床表现主要为尿频、尿急、膀胱充盈后耻骨上及会阴区疼痛。14例均依据美国糖尿病、消化及肾病协会（NIDDK）IC诊断标准确诊。采用膀胱水囊扩张后碳酸氢钠、利多卡因及肝素钠灌注治疗。治疗前后均行PST评分和PUF评分，并分析二者之间的关系。结果14例患者治疗前后PST评分中位数分别为4．0、1．0，PUF评分中位数分别为27．5、13．5，治疗前后差异均有统计学意义（P〈0．01）。PST评分与PUF评分呈正相关（治疗前rs=0．868，t=4．418，P=0．001；治疗后rs=0．779，t=4．300，P=0．001）。结论PST和PUF评分在IC中表现出一致性，可单独作为IC诊断、鉴别诊断、病情严重程度及治疗效果判定的重要指标。

Objective To discuss whether potassium sensitivity test（PST） is correlated with PUF in Interstitial Cystitis （IC）. Methods The data of 14 IC patients （female 13, male 1） were analyzed. The mean age was 48 years （range 35-67 years）. The clinical symptoms included urinary frequency, urgency, pelvic and peritoneal region pain after bladder filling. All the patients met the diagnostic criteria of NIDDK for IC. Dilatations by hyponome were performed, medicine including heparinsodium, lidocaine, NaHCO3 were used by intravesical instillation. PST and the pelvic pain and urgency/frequency patient symptom （PUF） were used for evaluation. The relationship of the PST and PUF was assessed by statistics. Results PST median decreased from 4.0 to 1.0 （P〈0.01）. PUF median decreased from 27.5 to 13.5（P〈0.01）. PST was directly correlated with PUF （rs =0. 868, t= 4. 418, P〈0. 001 before treatment, r5 = 0. 779, t=4. 300, P=0. 001 after treatment）. Conclusions PST and PUF are correlated. Both can be used as index in diagnosis, differential diagnosis, symptom severity and treatment effectiveness evaluation of IC.