摘要
目的观察中药糖耐康对自发性糖尿病大鼠尿蛋白的影响。方法将50只GK大鼠随机分为模型对照组、吡格列酮组、中药糖耐康低、中、高剂量组,另设正常对照组Wistar大鼠10只。各治疗组大鼠干预8周后,检测肾重/体重、尿蛋白等指标,同时光镜下观察肾小球病理变化。结果糖尿病模型组各项实验室指标与正常对照组比较均有显著差异,而吡格列酮组和糖耐康各剂量组经过8周干预后各项指标有所改善。治疗组肾小球内细胞外基质蓄积、基底膜的增厚及肾小球系膜细胞增生指标均明显改善。结论中药糖耐康能降低血糖,控制尿蛋白的排泄,并通过抑制大鼠糖尿病肾小球系膜细胞增生、基底膜基质合成以及肾小球内细胞外基质蓄积,从而改善肾小球的高滤过和高灌注,对糖尿病大鼠肾脏具有保护作用。
Objective： To investigate and explore the effect of Tangnaikang on urine protein in GK rats. Methods： 10 male Wister rats were divided into normal group, and 50 male GK rats were divided into five groups： model group, biglietong group, and Tangnaikang group（low, immediate and high dose） randomly. The KW/ BW, urine protein and pathological changes of glomeruli of kidney were detected after 8 weeks treatment. Results： The indices of model group had obvious difference with normal group, and those of biglietong group and Tangnaikang group improved, after 8 weeks treatment. The pathological changes of glomeruli of kidney of Tangnaikang group improved. Conclusions： Tangnaikang can decrease urine protein, and prevent and cure early diabetic mellitus nephropathy of rats.
出处
《中国中医急症》
2009年第4期579-580,614,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
高等学校博士学科点专项科研基金(No.20070026015)
