全反式维甲酸三氧化二砷联合化疗治疗急性早幼粒细胞性白血病的临床研究

Clinical Research on the Curative Effect of Combination Chemotherapy of All-trans Retinoic Acid and Arsenic Trioxide on Acute Promyelocytic Leukemia

目的:观察全反式维甲酸、三氧化二砷双诱导联合化疗对急性早幼粒细胞性白血病的疗效和特点.方法:对36例急性早幼粒细胞性白血病患者给予全反式维甲酸、三氧化二砷双诱导,达完全缓解后,序贯应用全反式维甲酸、三氧化二砷,联合小剂量化疗,观察缓解时间和药物不良反应.结果:36例中2例早期因脑出血而死亡,其余均完全缓解,完全缓解率达94.4%,达完全缓解的时间为21～70 d.结论:本方案治疗急性早幼粒细胞性白血病能够获得很高的完全缓解率,降低了复发率,缩短了诱导时间,可望长期生存,疗效确切、可靠.

Objective： To study the therapeutic effect and clinical features of the combination chemotherapy of all-trans retinoic acid and arsenic trioxide on acute promyelocytic leukemia. Methods： 36 cases of this disease underwent hi-inductive treatment with all-trans retinoic acid and arsenic trioxide at first. When the patients＇ conditions turned to complete remission they subsequently were treated with low-dose comhination chemotherapy of all-trans retinoic, acid and arsenic trioxide sequentially. The remission time and drug adverse reaction of this therapy were observed. Results： 2 patients died of cerebral hemorrhage at the early stage among 36 cases and the rest cases led to complete remission. The complete remission rate was 94.4% and the duration for complete remission ranged from 21 to 70 （lays. Conclusion： This method treating acute promyelocytic leukemia possesses the advantages of high complete remission rate, low recurrence rate, short induction time, patient＇ s long term survival, and affirmative and reliable curative effect.