霞水母胶原蛋白活性肽对小鼠免疫功能的影响

Effects of Collagen Peptide from Cyanea nozakii on Mice Immune Function

[目的]为霞水母胶原蛋白活性肽的临床应用提供理论依据。[方法]在探明霞水母胶原蛋白肽急性毒性反应的基础上,分别以25、50、100 mg/kg的剂量给小鼠连续灌胃30 d,然后进行小鼠吞噬细胞吞噬功能、迟发型超敏反应、血清溶血素的测定。[结果]霞水母胶原蛋白肽为实际无毒性或低毒性物质;试验组的3项免疫指标与空白对照组相比有显著(P<0.05)或极显著(P<0.01)差异。[结论]霞水母胶原蛋白活性肽具有一定的免疫增强作用。

[ Objective] The study aimed to provide a theoretical basis for the clinical application of collagen peptide from Cyanea nozakii. [ Method] After acute toxicity test on mice, collagen peptide from C. nozakii were given to mice by continuous intragastric administration for 30 d at the doses of 25,50, 100 mg/kg, and then the phagocytosis of macrophage, delayed type hypersensitivity （DTH） and serum hemolysin level were determined. [ Result ] Collagen peptide from C. nozakii was atoxic or low toxic, and the three immune indices of experimental groups were significantly higher than those of the control group （treated with the same volume of normal saline） at 0.05 or 0.01 level. [ Conclusion ] Collagen peptide from C. nozakii has a certain immunopotentiation.