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大鼠全身曝露N,N-二甲基甲酰胺蒸汽后血液中N-甲基氨基甲酸硫酯动态研究

KINETIC STUDY ON N METHYLFORMAYOL THIOESTERS IN RAT BLOOD AFTER WHOLE BODY EXPOSURE TO N,N DIMETHYLFORMAMIDE VAPORS
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摘要 报道了经恒定气相浓度N,N-二甲基甲酰胺(DMF)蒸汽曝露的雄性SD大鼠血液中以S-(N-甲基氨基甲酰)谷胱甘肽(SMG)为代表的N-甲基氨基甲酸硫酯的代谢生成及体内消长.实验所用封闭曝露系统内DMF蒸汽恒定浓度分别为φ=24×10-6(直至48h);φ=84×10-6及φ=213×10-6(均为72h).经(φ=24×10-6)×24h处理后,大鼠血清中N-甲基氨基甲酸硫酯达到稳态浓度47μmol/L,当DMF稳态蒸汽浓度φ=84×10-6时,体内血清N-甲基氨基甲酸硫酯稳态浓度为227μmol/L,在环境蒸汽浓度φ<84×10-6时,大鼠体内N-甲基氨基甲酸硫酯稳态浓度与环境中DMF蒸汽浓度呈线性关系.所产生的N-甲基氨基甲酸硫酯类物质体内半衰期在2.2~2.8h之间,体内半衰期值主要是由其生成速率决定的.高浓度DMF(φ=213×10-6)的曝露并未导致体内产生可检出水平的N-甲基氨基甲酸硫酯类物质,这可能是由于体内高浓度的DMF对其本身代谢的抑制作用所致. This paper deals with the occurence and kinetics of the N-methylformamyol thioesters, e.g. S-(N-methylcarbamoyl)glutathione(SMG) and S-(N-methylcarbamoyl)cystein(SMC) in male SD rat blood after exposure to N,N-dimethylformamide vapor at constant concentration. The constant vapor concentration of DMF in the closed exposure system is φ =24×10 -6 (exposure time 48 h), φ =84×10 -6 and φ =213×10 -6 (exposure time for both concentration 72 h), respectively. After φ =24×10 -6 x 24 h exposure a steady concentration of N-methylformamyol thioesters at 47 μ mol/L were reached. For φ =84×10 -6 ×72 h exposure 227 μ mol/L of N-methylformamyol thioesters, as a steady state concentration was recorded. It was found that up to φ <84×10 -6 ,a linearity between the steady state concentration of N-methylformamyol thioesters in the blood and the constant DMF vapor exposure concentration existed. The half life of N-methylformamyol thioesters in rat body after the end of exposure was 2.2~2.8 h. The value of half life, mainly, depends on its rate of formation. No N-methylformamyol thioesters at detectable level were found after high concentration exposure ( φ =213×10 -6 )due to possible inhibition of DMF to its own metabolism.
出处 《应用与环境生物学报》 CAS CSCD 1998年第1期32-36,共5页 Chinese Journal of Applied and Environmental Biology
关键词 二甲基甲酰胺 蒸气接触 血液 甲基氨基 甲酸硫酯 N N-dimethylformamide blood N-methylformamyol thioesters
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