摘要
以ＨｅｐＧ２．２．２．１５细胞株为模型，以其分泌的ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢＶＤＮＡ及细胞存活率为观察指标，综合评价天然多肽类抗生素恩拉霉素体外抗ＨＢＶ效果。结果表明恩拉霉素对ＨＢｓＡｇ和ＨＢｅＡｇ的５０％抑制浓度ＩＣ５０分别为２７μｇ／ｍＬ和３４μｇ／ｍＬ，治疗指数（ＴＩ）分别为５．９和４．６。Ｓｏｕｔｈｅｒｎ结果显示，５０μｇ／ｍＬ恩拉霉素对细胞内游离ＨＢＶＤＮＡ抑制率为５６．８％。
s\ Enduracidin was studied for its ability to inhibit Hepatitis B Virus DNA, HBsAg and HBeAg secreted by a HBV transfected cell line (HepG 2.2.2.15). The result showed that IC 50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%)was 27μg/mL and 34μg/mL respectively, theraputic index (TI) was 5.9 and 4.6. Enduracidin at the concentration of 50μg/mL inhibited 56.8% of the production of free HBV DNA in the Cells.
出处
《中国病毒学》
CSCD
1998年第1期45-49,共5页
Virologica Sinica
基金
国家自然科学基金
