摘要
目的:观察黄芩苷对家兔离体子宫平滑肌收缩的作用及其与Ca2+的关系。方法:制作常规离体家兔子宫平滑肌肌条,考察黄芩苷对子宫肌条反应的影响。结果:(1)黄芩苷(5-10mmol·L-1)剂量依赖抑制子宫平滑肌收缩;(2)黄芩苷对催产素及高K去极化液中Ca2+所致的离体子宫平滑肌收缩均呈剂量依赖性抑制;使CaCl2累积量-效曲线非平行性右移,最大效应下降,呈非竞争性抑制;(3)且对子宫平滑肌依细胞内、外Ca2+两种收缩成分均呈抑制作用。结论:黄芩苷对家兔离体子宫平滑肌条的抑制作用,可能与其拮抗Ca2+有关。
Objective： To investigate the contraction effect of baicalin on isolated uterus in rabbits. Methods： Conventional isolated uterine strips of rabbits were used to observe the reactions in different conditions. Results： （1） Isolated rabbit uterus smooth muscle contraction was dose-dependently inhibited by baicalin （5-10 mmol·L^-1）. （2） The contraction induced by oxytocin and Ca^2＋ after high K^＋ depolarization was dose-dependently inhibited by baicalin. The cumulativedose-response curves of CaCl2 shifted to right and the maximal responses were depressed, which showed that baicalin was a non competitive antagonist. （3） The extracellular and intracellular Ca^2＋ dependent contraction evoked by oxytocin could also be inhibited by baicalin. Conclusion： Baicalin could inhibit the contractility of the isolated uterus smooth muscle and might relate with inhibition Ca^2＋.
出处
《现代生物医学进展》
CAS
2009年第6期1044-1047,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金:平滑肌肌球蛋白活性的双向调节研究项目(30772601)
