AnnexinⅡ和AnnexinIV在大肠癌中的表达及其临床意义

Expression of Annexin Ⅱand Annexin IV in Colorectal Carcinoma Tissues and Its Clinical Significance

目的:探讨AnnexinⅡ和Annexin IV在大肠癌中的表达及其临床意义。方法:用免疫组化SP法分别检测AnnexinⅡ和Annexin IV在60例大肠癌组织中的表达。结果:(1)AnnexinⅡ和Annexin IV在大肠癌组织中的阳性表达率分别为65%(39/60)和60%(36/60);(2)AnnexinⅡ和Annexin IV阳性和阴性病例的平均生存期、五年生存率和中位生存期比较,差异具有显著性(P<0.05);(3)大肠癌组织中AnnexinⅡ和Annexin IV的表达一致率为68.33%(41/60),存在显著相关性(P<0.01);(4)大肠癌不同临床时期(Ⅱ、Ⅲ和Ⅳ)AnnexinⅡ和Annexin IV阳性表达比较,差异具有显著性(P<0.01)。结论:AnnexinⅡ和Annexin IV与大肠癌的临床分期和预后有关。

Objective： To investigate expression of Annexin Ⅱ and Annexin Ⅳ in colorectal carcinoma and its clinical significance. Methods： Expression of Annexin Ⅱ and Annexin Ⅳ were assayed respectively in 60 colorectal carcinoma tissue by immunohistochemistry. Results： （1） The positive rates of Annexin Ⅱ and Annexin Ⅳ in colorectal carcinoma were 65%（39/60） and 60%（36/60） respectively. （2） The mean survival period, the five-year-survival rate and median survival period in Annexin Ⅱ and Annexin Ⅳ positive expression group were shorter than that ofAnnexin Ⅱ and Annexin Ⅳ negative expression group （P〈0.05）. （3）The coincidence expression rate of Annexin Ⅱ and Annexin Ⅳ was 68.33% （41/60）, and the correlation analysis showed significance between Annexin Ⅱ and Annexin Ⅳ （P 〈0.01）. （4） In stage Ⅱ, Ⅲ and Ⅳ ofcolorectal carcinoma, there is significant difference between Annexin Ⅱ and Annexin Ⅳ expression （P〈0.05）. Conclusion： Annexin Ⅱ and Annexin Ⅳ were related to prognosis and clinical stage ofcolorectal carcinoma.