摘要
尿毒素三肽UTPA,UTPB和UTPC分别与氢化可的松缀合,得到4种缀合激素。与尿毒素三肽或氢化可的松相比,缀合激素可延长不同种属小鼠异位移植(Heterotopictransplatation)心肌的存活时间;与氢化可的松和尿毒素三肽的机械混合物相比,低浓度下缀合激素可增强对淋巴细胞增殖的抑制作用。表明缀合激素有一定的免疫抑制作用。
Hydrocortisone was coupled with urotoxin tripeptide UTPA, UTPB and UTPC respectively yielding 4 linkers. Their bioactivities such as prolongation of heterotopic transplanted cardiac tissue survival, inhibitory effects on phagocytosis of mouse peritoneal macrophages and the influence on Con A induced proliferation of spleen lymphocytes of mouse were observed. Compared with UTPA, UTPB, UTPC or hydrocortisone the linkers were more potent immunosuppressants. The results suggest that the linker of steroidpeptide may simulate the permissive action.
出处
《药学学报》
CAS
CSCD
北大核心
1998年第2期111-116,共6页
Acta Pharmaceutica Sinica
基金
国家教委博士点基金