豹皮菌中2-Amino-3-(1,2-dicarboxyethylthio)propanoic acid非对映异构体的绝对构型

ABSOLUTE CONFIGURATION OF THE DIASTEREOISOMER OF 2AMINO3(1,2DICARBOXYETHYLTHIO) PROPANOIC ACID FROM AMANITA PANTHERINA

豹皮菌中２Ａｍｉｎｏ３（１，２ｄｉｃａｒｂｏｘｙｅｔｈｙｌｔｈｉｏ）ｐｒｏｐａｎｏｉｃａｃｉｄ非对映异构体的绝对构型顾谦群伏谷真二野副重男（青岛海洋大学海洋药物与食品研究所，青岛２６６００３；东北大学药学部，日本仙台）豹皮菌（Ａｍａｎｉ...

Four stereoisomers of 2amino3(1,2dicarboxyethylthio) propanoic acid were prepared by reaction of L and Dcysteine with fumaric acid. The absolute configuration of the diastereoisomer of 2amino3(1,2dicarboxyethylthio) propanoic acid from Amanita pantherina were assigned as (2R, 1'R) and (2R, 1'S) by analysis of the optical properties. Pharmacological tests showed that all of the four stereoisomers inhibited the depolarization of NMDA on spinal motorneurones in newborn rats, The inhibition intensity of LA, DA and DB were higher than that of LB.