摘要
豹皮菌中2Amino3(1,2dicarboxyethylthio)propanoicacid非对映异构体的绝对构型顾谦群伏谷真二野副重男(青岛海洋大学海洋药物与食品研究所,青岛266003;东北大学药学部,日本仙台)豹皮菌(Amani...
Four stereoisomers of 2amino3(1,2dicarboxyethylthio) propanoic acid were prepared by reaction of L and Dcysteine with fumaric acid. The absolute configuration of the diastereoisomer of 2amino3(1,2dicarboxyethylthio) propanoic acid from Amanita pantherina were assigned as (2R, 1'R) and (2R, 1'S) by analysis of the optical properties. Pharmacological tests showed that all of the four stereoisomers inhibited the depolarization of NMDA on spinal motorneurones in newborn rats, The inhibition intensity of LA, DA and DB were higher than that of LB.
出处
《药学学报》
CAS
CSCD
北大核心
1998年第1期64-66,共3页
Acta Pharmaceutica Sinica
关键词
豹皮菌
非对映异构体
构型
担子菌
神经毒物质
Amanita pantherina
2Amino3(1
2dicarboxyethylthio) propanoic acid
Absolute configuration