2,3-苯并吡喃酮类化合物的合成及药理活性

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2,3-BENZOPYRONE ANALOGS

２，３苯并吡喃酮类化合物的合成及药理活性季小慎梁晓天（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）在研究番荔枝酰胺全合成的过程中［１］，曾将乙酰化高丁香酸甲酯和香草醛在Ａｃ２Ｏ／ＺｎＣｌ２条件下作用，以期获得如下Ｋｎｏｅｖｅｎａ...

Several 2,3 benzopyrone analogs were synthesized for evaluating their K + channel and anticancer activities. The Friedel Crafts reaction was taken place with some replacement phenyl acetic acid or its methyl ester and vanillin as reactants in the condition of Ac 2O/ZnCl 2. All products were confirmed by means of MS and 1H, 13 CNMR spectra. Compounds 2 and 3 showed obvious activities on the K + channel and anticancer screening, while the activity of compound 5 was weak. Compound 4 was not yet tested. The primary result indicate that the potential activity of such compounds deserves further study.