癌周粘膜下药物注射辅助手术治疗直肠癌近期疗效观察

EFFECT OF ADJUVANT SUBMUCOSAL INJECTION OF ANTITUMOR DRUGS AROUND RECTAL CANCER

３８例直肠癌术前行癌周粘膜下注射抗癌药物（５－Ｆｕ，丝裂霉素，卡铂），注射１次者９例，２次者１７例，３次者１２例。术后根据肿瘤原发灶及其淋巴结内转移癌组织变性、坏死的程度判断其疗效。原发灶有效率为８４．２％；３８例中３１例查到有癌细胞转移的阳性淋巴结共１７８个，１５６个淋巴结内可观察到癌细胞坏死、变性，有效率为８７．６％。

Thirtyeight cases of rectum cancer were treated with multiple points submucosa injection of antineoplasm drugs(5Fu,MMC and CBP)around tumor.9 cases were injected once,12 cases twice and the rest 17 cases 3 times(average 2.2 times).All the patients were operated on one or two days after injection.The effect of injection was judged by the degree of degeneration and necrosis of primary tumor cells and that of metastasis within lymphaden under microscopic examination.The effective rate of the treatment on primary tumor was 84.2%.Of the 178 positive lymphatic nodes detected in 31 cases and observed under microscope degeneration and necrosis of cancer cells in various degrees were found in 156 lymphatic nodes,the effective rate being 87.6%.